Scientists discover hidden differences among cells that may help them evade drug therapy

University of Maryland researchers have discovered that seemingly identical cells can use different protein molecules to carry out the same function in an important cellular process. The scientists named this newly discovered variability “functional mosaicism,” and it has significant implications for the development of therapeutic treatments, which are often designed Continue Reading

Researchers discover a new mechanism that could counteract obesity

Obesity rates worldwide have nearly tripled since 1975. Now, new research from the University of Minnesota Medical School has discovered, in rodents, critical mutations in molecules implicated in obesity, which may help inform the development of new anti-obesity therapies. Lead author Alessandro Bartolomucci, Ph.D., Associate Professor in the Department of Continue Reading

Biophysicists discover how ‘Australian’ mutation leads to Alzheimer’s disease

A team of scientists from the Moscow Institute of Physics and Technology (MIPT) and Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (IBCh RAS) studied one hereditary genetic mutation to discover general molecular mechanisms that may lead both to early onset of Alzheimer’s disease and to the form of the disease caused by Continue Reading

Researchers discover that fasting reduces inflammation and improves chronic inflammatory diseases

Fasting regimens have gained public and scientific interest in recent years, but fasting shouldn’t be dismissed as a fad. In a study published in Cell, Mount Sinai researchers found that fasting reduces inflammation and improves chronic inflammatory diseases without affecting the immune system’s response to acute infections. While acute inflammation Continue Reading

Researchers discover blocking key mineral uptake could prevent gonorrhea infection

Blocking the ability of the bacterial pathogen that causes gonorrhea to uptake the mineral zinc can stop infection by this widespread sexually transmitted infection, according to a study by the Institute for Biomedical Sciences at Georgia State University. The findings, published in the journal PLoS Pathogens, could be used to Continue Reading

Scientists discover immune cell subtype in mice that drives allergic reactions

Allergies can be life-threatening when they cause anaphylaxis, an extreme reaction with constriction of the airways and a sudden drop in blood pressure. Scientists have identified a subtype of immune cell that drives the production of antibodies associated with anaphylaxis and other allergic reactions. The research was funded by the Continue Reading

Researchers discover therapy to treat drug-resistant acute lymphoblastic leukemia

Acute lymphoblastic leukemia accounts for one in five adult leukemias, and is the most common pediatric cancer in the United States. While new immune therapies have helped improve survival rates, some patients are unresponsive to existing treatment regimens. In addition, drug-related toxicities and drug resistance are rampant for these patients, Continue Reading

Scientists discover previously unknown subtypes of liver cells in health and disease

Single cells were isolated from liver tissue derived from 9 different patients to perform single-cell RNA-sequencing. After applying computational single-cell analysis methods, a human liver cell atlas, or cell type map, was established, enabling the identification of previously unknown sub-types (depicted as clusters represented by numbers on the map). We Continue Reading

Researchers discover the Achilles’ heel of an aggressive brain cancer

Glioblastoma is the most prevalent and also the most lethal type of brain tumour in adults, with no curative treatment currently available. Glioblastomas cannot be surgically completely excised, as the tumour cells are adept at invading tissues and spreading around the brain. In addition, glioblastoma cells are extremely resistant to Continue Reading