Understanding connection between poverty, childhood trauma and heart disease

Traumatic childhood experiences among the poor and uninsured are associated with higher cardiovascular risk, according to new research. Experts have long known difficult childhoods are linked with a wide range of health risks later in life, including obesity, substance abuse and cardiovascular disease. They’re also alarmingly common: More than half Continue Reading

Total heart disease deaths on the rise

Total deaths from heart disease, stroke, diabetes and hypertension—known collectively as cardiometabolic disease—have been increasing since 2011, a new Northwestern Medicine study shows. Cardiometabolic disease is the leading cause of preventable death worldwide. While the overall rate of heart disease deaths decreased over time, the rate of decline slowed after Continue Reading

Noninvasive monitoring of chronic kidney disease (CKD) using pH and perfusion imaging

Chronic kidney disease (CKD) is a feature of inherited metabolic disorders such as methylmalonic acidimia (MMA), which can cause impaired growth and low metabolic activity to delay the diagnosis and management of renal disease. In a new report now published on Science Advances, KowsalyaDevi Pavuluri and colleagues at the interdisciplinary Continue Reading

Biophysicists discover how ‘Australian’ mutation leads to Alzheimer’s disease

A team of scientists from the Moscow Institute of Physics and Technology (MIPT) and Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (IBCh RAS) studied one hereditary genetic mutation to discover general molecular mechanisms that may lead both to early onset of Alzheimer’s disease and to the form of the disease caused by Continue Reading

Type 2 diabetes risk up with inflammatory bowel disease

(HealthDay)—Patients with inflammatory bowel disease (IBD) have increased risk of type 2 diabetes, according to a study published online Aug. 5 in Clinical Gastroenterology and Hepatology. Tine Jess, M.D., from the Bispebjerg and Frederiksberg Hospital in Copenhagen, Denmark, and colleagues conducted a nationwide population-based cohort study involving 6,028,844 persons in Continue Reading

Protein aggregation: Protein assemblies relevant not only for neurodegenerative disease

Amyloid fibrils play a crucial role in neurodegenerative illnesses. Scientists from Heinrich Heine University Düsseldorf (HHU) and Forschungszentrum Jülich have now been able to use cryo-electron microscopy (cryo-EM) to decode the spatial structure of the fibrils that are formed from PI3K SH3 domains—an important model system for research. Although the Continue Reading

Huntington’s disease triggered by genetic instability in brain cells, study finds

Huntington’s disease is triggered by genetic instability of a particular DNA sequence in brain cells, according to a new study of the lethal neurodegenerative disorder. If confirmed, the study could lead to new methods to prevent disease onset. It could also result in more accurate prediction of when healthy carriers Continue Reading