Why young females with obesity are at early risk for cardiovascular disease

In the face of obesity, the sex hormone progesterone that helps females get and stay pregnant appears to also put them at increased, early risk for cardiovascular disease, investigators report. Premenopausal women are considered protected from cardiovascular disease, but evidence indicates obesity can negate those benefits, and in fact put Continue Reading

New drug may protect against memory loss in Alzheimer’s disease

A new drug discovered through a research collaboration between the University at Buffalo and Tetra Therapeutics may protect against memory loss, nerve damage and other symptoms of Alzheimer’s disease. Preclinical research found that the drug—called BPN14770—deters the effects of amyloid beta, a hallmark protein of Alzheimer’s that is toxic to Continue Reading

‘Tiny fat bubbles’ can boost immunity, calm disease

People living with inflammatory autoimmune disease could benefit from an “immune system reboot,” and researchers have isolated specific cells to target. The University of Queensland’s Professor Ranjeny Thomas said the research findings give hope for similar new immunotherapies for people with diseases like rheumatoid arthritis and vasculitis. “People with these Continue Reading

Apathy as an indicator of progression in Huntington’s disease

Researchers from the brain cognition and plasticity group of the Bellvitge Biomedical Research Institute (IDIBELL) and the Neuroscience Institute of the University of Barcelona (UBNeuro) have led an innovative study that identifies modifications in the connectivity of cerebral white matter associated with the heterogeneous nature of apathy in Huntington’s disease Continue Reading

Possible treatment breakthrough for the rare disease arrhythmogenic right ventricular cardiomyopathy

Arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5) is a fatal genetic disease for which there is unfortunately no cure. Now, scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Puerta de Hierro Majadahonda Hospital (Spain) have discovered a possible treatment for this rare disease. The research team, whose findings Continue Reading

Artificial intelligence approaches may improve diagnostics of kidney disease

Two new studies reveal that modern machine learning—a branch of artificial intelligence in which systems learn from data, identify patterns, and make decisions—may augment traditional diagnostics of kidney disease. The findings appear in an upcoming issue of JASN. Pathologists often classify various kidney diseases on the basis of visual assessments Continue Reading

Progress in understanding Alzheimer’s disease genetics, hope remains for drugs in testing

What is happening with Alzheimer’s disease research and treatment? We heard from Maria Carrillo, chief science officer of the nationwide Alzheimer’s Association, during a recent visit to San Diego. Here are some questions and answers from the interview, edited for space and clarity. Q: There have been several failed clinical Continue Reading

Research into Parkinson’s disease: Binding-protein prevents fibril proliferation

Protein aggregates have been observed in the nerve tissue of patients with Parkinson’s disease which consist of individual components (monomers) of the protein α-synuclein which assemble into what are referred to as amyloid fibrils. Similar deposits are also found in the case of other neurodegenerative diseases such as Alzheimer’s. Researchers Continue Reading