Super-resolution microscopy sheds light on how dementia protein becomes dysfunctional

University of Queensland researchers have used super-resolution microscopy to observe key molecules at work inside living brain cells, further unravelling the puzzle of memory formation and the elusive causes of dementia. UQ Queensland Brain Institute’s Clem Jones Centre for Ageing and Dementia Research Professors Frédéric Meunier and Jürgen Götz found Continue Reading

DNA-protective protein could help clinicians better target fast-growing cancer cells

The discovery that an essential protein plays a protective role during cell division, could open the door to better targeted treatment of fast-growing cancer cells. Polo-like kinase (PLK1) was previously thought to have a major function—helping chromosome alignment during mitosis for cell division. But scientists at the Genome Damage and Continue Reading

Alzheimer’s protein is likely held together with many weak chemical interactions

The chemical interactions that give proteins their shape may be weaker and more numerous than previously recognized. These weak connections provide a new way for researchers to understand proteins that cause disease and help them gain insights into the fundamentals of chemistry. Chemists at the University of Tokyo modeled the Continue Reading

Researchers map protein-gene interactions involved in Alzheimer’s disease

Among the confounding challenges of diagnosing and treating Alzheimer’s disease (AD) is the fact that patients with asymptomatic and symptomatic versions of the degenerative condition may share similar neuropathological burdens but experience significantly different rates of cognitive decline. In a new study, published July 23, 2019 in Cell Reports, a Continue Reading

Sorting protein in neurons defends against neurodegenerative disease

Domenico Praticò, MD, Scott Richards North Star Foundation Chair for Alzheimer’s Research, Professor in the Departments of Pharmacology and Microbiology, and Director of the Alzheimer’s Center at Temple at the Lewis Katz School of Medicine at Temple University Credit: Lewis Katz School of Medicine at Temple University Like a sorting Continue Reading

Hinge-like protein may open new doors in cystic fibrosis treatment

A potentiator (orange) binds to a protein ‘hotspot,’ altering the molecule’s conformation. Credit: Laboratory of Membrane Biology and Biophysics at The Rockefeller University In recent decades, treatment options for people with cystic fibrosis have improved dramatically. The newest drugs, known as potentiators, target a protein called cystic fibrosis transmembrane conductance Continue Reading