Researchers describe the epigenetic fingerprints everyday experiences leave in neurons

An international study led by researchers from the Instituto de Neurosciencias, UMH-CSIC in Alicante presents a novel multi-omic analysis of the changes in the organization of the genetic material of neurons triggered by neuronal activation both in a pathological (epilepsy) and physiological context (learning and memory). Some of these changes Continue Reading

Researchers discover a new mechanism that could counteract obesity

Obesity rates worldwide have nearly tripled since 1975. Now, new research from the University of Minnesota Medical School has discovered, in rodents, critical mutations in molecules implicated in obesity, which may help inform the development of new anti-obesity therapies. Lead author Alessandro Bartolomucci, Ph.D., Associate Professor in the Department of Continue Reading

Researchers identify biomarker to predict if someone infected with malaria will get sick

Immunological signatures can predict whether malaria-infected children will develop fever or other symptoms, suggests a study publishing September 3 in the journal Immunity. Surprisingly, activation of the well-known tumor-suppressor protein p53 is associated with enhanced protection against malaria fever—and increasing p53 in human immune cells and in mice results in Continue Reading

Researchers develop novel heart pump to help people with heart failure

Dr. David Adlam, associate professor and interventional cardiologist in the Department of Cardiovascular Sciences and Piyal Samara-Ratna, Mechanical Engineer in the Space Research Centre, have joined forces to combine medical and space research to develop a pump to help people with heart failure. The new left ventricular assist device (LVAD) Continue Reading

Researchers uncover how popular drug helps in heart failure

Results were released today from the first two clinical studies designed specifically to examine the effects of the heart drug sacubitril/valsartan on the structure and function of the failing heart. Treatment with sacubitril/valsartan, a combination angiotensin receptor-neprilysin inhibitor (ARNI), substantially lowers rates of death and hospitalization in certain types of Continue Reading

Researchers study how the insular cortex processes negative emotions and bodily states

The insular cortex is an important, yet almost hidden part of the cerebral cortex. Here, sensory information, bodily states, feelings and emotions come together. However, how the insular cortex processes this information and how this affects behavior is largely unknown—knowledge that would help us to better understand the mechanisms involved Continue Reading