Harms and benefits of estrogen therapy among women with a hysterectomy appear to depend on age when therapy was started

Patients who started estrogen over the age of 60 did not derive a mortality benefit and experienced more adverse effects particularly among those 70 and older, regardless of whether they had their ovaries removed. While no statistically significant benefit was seen in the initial study average follow-up period of 7 Continue Reading

Algorithm based on response, biology guides neuroblastoma therapy

(HealthDay)—Use of a response- and biology-based treatment algorithm for intermediate-risk neuroblastoma is associated with excellent survival and reduces treatment for some patients, according to a study published online Aug. 6 in the Journal of Clinical Oncology. Clare J. Twist, M.D., from the Roswell Park Cancer Institute in Buffalo, New York, Continue Reading

Behavioral therapy, physical strengthening may prevent disability in minority elders

A randomized controlled trial of a new disability prevention intervention, called Positive Minds-Strong Bodies (PMSB), indicates that improving coping skills and physical strengthening can significantly improve functioning and mood in racial and ethnic minority and immigrant older adults. A report on this multi-site clinical trial is being published in the Continue Reading

Combinatorial therapy shows early promise in patients with relapsed small cell lung cancer

The PARP inhibitor olaparib (Lynparza) in combination with the chemotherapeutic agent temozolomide (Temodar) showed clinical efficacy in patients with relapsed small cell lung cancer (SCLC), according to results from a phase I/II clinical trial published in Cancer Discovery, a journal of the American Association for Cancer Research. “Small cell lung Continue Reading

MDM2 counteracts resistance to CDK4/6 inhibitors for melanoma therapy

A study from Vanderbilt-Ingram Cancer Center and the Department of Veterans Affairs led by Anna Vilgelm, MD, Ph.D., and Ann Richmond, Ph.D., has identified a possible second-line treatment for melanoma patients. The potential treatment would render CDK4/6 inhibitors, a class of drugs prescribed for some breast cancers, also effective against Continue Reading

Novel dual stem cell therapy improving cardiac regeneration

As a medical emergency caused by severe cardiovascular diseases, myocardial infarction (MI) can inflict permanent and life-threatening damage to the heart. A joint research team comprising scientists from City University of Hong Kong (CityU) has recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems Continue Reading

Pancreatic cancer: Less toxic, more enduring drug may improve therapy

Unlike many other cancers, most pancreatic tumors are rock hard.  “That’s one reason why pancreatic cancer is one of the most lethal types of cancer,” says Kenneth Olive, Ph.D., associate professor of medicine and pathology & cell biology at Columbia University Vagelos College of Physicians and Surgeons and a pancreatic cancer researcher Continue Reading

New research points to potential therapy for abnormal touch sensitivity in autism spectrum disorders

The inability to tolerate light touch is a telltale feature of autism and one of the disorder’s many perplexing symptoms. It has defied treatment, and its precise origins have remained somewhat of a mystery. Now a study led by investigators at Harvard Medical School’s Blavatnik Institute has not only identified Continue Reading