Stem cell treatments for shoulder and elbow injuries flourish, but so far there’s little evidence they work

The utilization of stem cell therapies for augmentation of tissue healing has far outpaced the supporting scientific and clinical data, largely due to aggressive marketing that has led to widespread and often inappropriate use of cell therapy approaches in the United States. Two critical reviews in the Journal of Shoulder Continue Reading

Is this brain cell your ‘mind’s eye’?

No-one knows what connects awareness鈥攖he state of consciousness鈥攚ith its contents, i.e. thoughts and experiences. Now researchers propose an elegant solution: a literal, structural connection. ‘Content circuits’ within the cortex are plugged into ‘switchboard circuits’ that allocate awareness, says the theory, via cortical cells called L5p neurons. Writing in Frontiers in Continue Reading

First CAR T cell therapy targeting B cell-activating factor receptor eradicates blood cancers

The first CAR T cell therapy targeting the B cell-activating factor receptor on cancerous cells eradicated CD19-targeted therapy-resistant human leukemia and lymphoma cells in animal models, according to City of Hope research published today in Science Translational Medicine. The new therapy will be used in a clinical trial next year Continue Reading

CAR T cell therapy: On the cusp of ‘an immunotherapy revolution’?

A deeper understanding of the immune system’s role in controlling cancer has helped drive “an immunotherapy revolution,” offering hope for many patients with previously incurable cancers, including children, doctors have concluded in a new report. The assessment, from two Stanford University doctors, is part of their broader analysis on lessons Continue Reading

Novel regulator of mitochondrial cell death reveals a promising target for cancer therapy

Researchers at The Wistar Institute have described the role of mitochondrial fission factor (MFF) in controlling survival of cancer cells, suggesting the protein could represent a promising therapeutic target. They also found that expression of MFF is regulated by Myc, a ubiquitous mediator of cell proliferation that contributes to development Continue Reading

Diverse immune cell profiles and roles found in breast cancer resistance to immunotherapy

In recent years it has been increasingly appreciated that immune cells within the tumor microenvironment contribute to tumor progression and, importantly, to the tumor’s response to therapy. To better understand the specific roles different immune cell types play, a multi-institutional team led by researchers at Baylor College of Medicine profiled Continue Reading