Genetic markers linked to the start of symptoms of Parkinson’s disease

Researchers from the Institute of Neurosciences of the University of Barcelona (UBNeuro), Hospital Clínic and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) have identified a group of genetic variants related to the starting point of Parkinson’s disease. These results, published in the journal Movement Disorders, will enable delimiting Continue Reading

Study shines light on architecture of kidney disease

A study of 280,000 U.S. veterans including 56,000 African Americans has identified in greater detail than ever before the “genetic architecture” of kidney function and chronic kidney disease (CKD), according to researchers at Vanderbilt University Medical Center and their colleagues. The report, published recently in the journal Nature Communications, is Continue Reading

The toll dental disease can take

In 2007, a 12-year-old boy from Maryland died after an infection from an untreated dental abscess spread to his brain. His mother, homeless and dependent on Medicaid, had been unable to find a dentist to treat her children’s decaying teeth. Mary Otto, a reporter for the Washington Post, wrote about Continue Reading

Immune response against Toxocara roundworms helps explain disease

Neurotoxocarosis (NT) occurs in humans when larvae of the Toxocara roundworm migrate into the central nervous system. That infection is accompanied by a complex molecular signaling cascade, including changes to anti-inflammatory lipid molecules, researchers now report in PLOS Neglected Tropical Diseases. Toxocara roundworms are globally distributed and carried by animals Continue Reading

Tracking Alzheimer’s disease pathology in single neuronal cells

University of Warwick researchers have developed a superior method to describe the very earliest effects that Alzheimer’s Disease proteins have on the properties of brain cells. In the paper “Introduction of Tau oligomers into cortical neurons alters action potential dynamics and disrupts synaptic transmission and plasticity,” published in the journal Continue Reading

How and why does Parkinson’s disease effect women and men differently?

There is growing evidence that Parkinson’s disease (PD) affects women and men differently. In this insightful review, published in the Journal of Parkinson’s Disease, scientists present the most recent knowledge about these sex-related differences and highlight the significance of estrogens, which play an important role in the sex differences in Continue Reading