Drug rediscovery protocol allows doctors to prescribe anticancer drugs outside of their approved use

A large team of researchers affiliated with institutions across the Netherlands has begun what they call a Drug Rediscovery protocol—a clinical trial of sorts that involves giving cancer patients anticancer drugs that are not typically used for their type of cancer. In their paper published in the journal Nature, the Continue Reading

Targeted therapy drug helps women with aggressive breast cancer live longer

A study led by UCLA researchers found that adding ribociclib, a targeted therapy drug, to standard hormone therapy has been shown to significantly improve overall survival in postmenopausal women with advanced hormone-receptor positive/HER2- breast cancer, one of the most common forms of the disease. The results were presented during the Continue Reading

Two immunotherapy drug combination offers chemotherapy-free option for advanced NSCLC

New data have shown that first-line treatment with a combination of two immunotherapy drugs improves overall survival in a subset of patients with advanced non-small cell lung cancer (NSCLC) compared to chemotherapy. The data from the CheckMate-227 trial, reported at the ESMO Congress 2019, suggest that the combination of nivolumab Continue Reading

Treating C. difficile infections: New purpose for an old drug?

Common in hospitals and nursing homes, Clostridioides difficile聽infection (CDI) is a major health threat, particularly for older patients. According to a 2015 study by the Centers for Disease Control and Prevention, in the U.S. the infection claims some 15,000 lives per year. Certain antibiotics, by disrupting normal gut microorganisms (microbiota), Continue Reading

Scientists tackle potential drug resistance by using new single-cell genetic method

Using a new technique that can identify genetic profiles of individual cells, University of Notre Dame researchers modeled a breast cancer tumor’s potential resistance to a drug, and then identified a drug combination that reversed that resistance. Siyuan Zhang, the Dee Associate Professor of Biological Sciences at Notre Dame, and Continue Reading

Cheaper drug just as effective protecting heart in Duchenne muscular dystrophy

A new clinical trial conducted at The Ohio State University Wexner Medical Center found a cost-effective generic medication works just as well as a more expensive drug in preserving cardiovascular function in boys with Duchenne muscular dystrophy (DMD). Results of this multi-center trial are in today’s Journal of the American Continue Reading

Promising drug candidate could stop malaria parasites at multiple stages

Redesigning molecules originally developed to treat the skin disease psoriasis could lead to an effective new drug against malaria, according to an international team of researchers. The team modified a class of molecules called pantothenamides to increase their stability in humans. The new compounds stop the malaria parasite from replicating Continue Reading