Drug rediscovery protocol allows doctors to prescribe anticancer drugs outside of their approved use

A large team of researchers affiliated with institutions across the Netherlands has begun what they call a Drug Rediscovery protocol—a clinical trial of sorts that involves giving cancer patients anticancer drugs that are not typically used for their type of cancer. In their paper published in the journal Nature, the Continue Reading

Study gives clues to the origin of Huntington’s disease, and a new way to find drugs

The first signs of Huntington’s, an inherited disease that slowly deteriorates bodies and minds, don’t typically surface until middle age. But new findings suggest that something in the brain might be amiss long before symptoms arise, and earlier than has ever been observed. Using a new technology, Rockefeller scientists were Continue Reading

Gene-targeted cancer drugs, slow release overcome resistance

Biomedical engineers at Duke University have developed a method to address failures in a promising anti-cancer drug, bringing together tools from genome engineering, protein engineering and biomaterials science to improve the efficacy, accuracy and longevity of certain cancer therapies. Using a combination of CRISPR-based targeting, a protein “depot” that allows Continue Reading

Study finds certain drugs used to treat eye diseases excreted into human breast milk

Certain drugs used to treat retinal diseases are excreted into breast milk, raising possible safety concerns for developing infants, suggests a first-of-its-kind study led by St. Michael’s Hospital in Toronto and published in Ophthalmology. Ranibizumab and aflibercept are medications used to treat several retinal diseases. They contain an agent called Continue Reading