Immune therapy eliminates tumour cells in early triple negative breast cancer

Immune therapy added to chemotherapy improves pathological complete response in patients with early triple negative breast cancer, according to late breaking results from the KEYNOTE-522 trial presented at the ESMO Congress 2019 in Barcelona, Spain. Interim results from the study, which is the first phase III trial of immunotherapy in Continue Reading

Immune response against Toxocara roundworms helps explain disease

Neurotoxocarosis (NT) occurs in humans when larvae of the Toxocara roundworm migrate into the central nervous system. That infection is accompanied by a complex molecular signaling cascade, including changes to anti-inflammatory lipid molecules, researchers now report in PLOS Neglected Tropical Diseases. Toxocara roundworms are globally distributed and carried by animals Continue Reading

Genomic map implicates broad immune cell involvement in multiple sclerosis

The International Multiple Sclerosis Genetic Consortium (IMSGC) reports the results of its latest study, “Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility”, in the journal Science today: the highly productive collaborative group presents a new milestone in its efforts to understand the genetic basis of multiple Continue Reading

Quality control in immune communication: Chaperones detect immature signaling molecules

The cells of our immune system constantly communicate with one another by exchanging complex protein molecules. A team led by researchers from the Technical University of Munich (TUM) has now revealed how dedicated cellular control proteins, referred to as chaperones, detect immature immune signaling proteins and prevent them from leaving Continue Reading

Resistance to immune checkpoint blocker drug linked to metabolic imbalance

A metabolic imbalance in some cancer patients following treatment with a checkpoint inhibitor drug, nivolumab, is associated with resistance to the immunotherapy agent and shorter survival, report scientists from Dana-Farber Cancer Institute, in collaborative work with the Broad Institute of MIT and Harvard. The chemical change, which the investigators say Continue Reading

Too much of a good thing: Overactive immune cells trigger inflammation

Scientists describe a previously unknown disorder of the immune system: in a distinct subset of immune cells from patients with primary immunodeficiency, cellular respiration is significantly increased. This cellular metabolic overactivity leads to inflammation, as an international research team led by the University of Basel and University Hospital Basel report Continue Reading

How IL-6 allows the immune response to develop for a key cell, the T follicular helper

The body’s immune response fights against infectious disease, and it safeguards against future infections through vaccination. However, if the immune response dysfunctions and attacks the body itself, it can cause autoimmune disease. Thus, a healthy immune response balances an instant readiness to combat infecting viruses or bacteria, while maintaining benign Continue Reading

Researcher studies differences in the immune systems of men and women

Females are less susceptible to infection but are 10 times more likely than males to develop an autoimmune disorder, such as hypothyroidism or rheumatoid arthritis. The female immune system is “a double-edged sword” in that way, said Jennifer Franko, a teaching assistant professor in the Department of Microbiology, Immunology and Continue Reading