Stem cell treatments for shoulder and elbow injuries flourish, but so far there’s little evidence they work

The utilization of stem cell therapies for augmentation of tissue healing has far outpaced the supporting scientific and clinical data, largely due to aggressive marketing that has led to widespread and often inappropriate use of cell therapy approaches in the United States. Two critical reviews in the Journal of Shoulder Continue Reading

Brain stem cells have a good memory

The cerebral cortex acts as the control centre of our cognitive processes. During embryogenesis, dozens of types of neurons with distinct functions come together to form the circuits that drive our thoughts and actions. These neurons are generated by progenitor cells, which produce them one after the other in a Continue Reading

Mini-kidneys grown from stem cells provide new insights into kidney disease and potential therapies

An international team of researchers led by Nanyang Technological University, Singapore (NTU Singapore) has grown ‘miniature kidneys’ in the laboratory that could be used to better understand how kidney diseases develop in individual patients. The mini kidneys, known as kidney organoids, were grown outside the body from skin cells derived Continue Reading

Profiling the stem-cell characters in the story of stomach lining renewal

Using an unbiased labeling technique, mathematical modeling, and single cell profiling to trace the footsteps of stem cells and their daughters, researchers at the University of Cambridge (UK), DGIST (S.Korea), and IMBA (Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria) have confirmed that two populations of adult Continue Reading

Novel dual stem cell therapy improving cardiac regeneration

As a medical emergency caused by severe cardiovascular diseases, myocardial infarction (MI) can inflict permanent and life-threatening damage to the heart. A joint research team comprising scientists from City University of Hong Kong (CityU) has recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems Continue Reading

Implantable 3-D blastocyst-like embryonic structure generated from mouse stem cells

An international collaboration of researchers from the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan and Gladstone Institutes in the U.S. have generated 3-D blastocyst-like structures from stem cells. Published in the journal Stem Cell Reports, the study shows that the blastocyst-like structures very closely resemble actual blastocysts, and Continue Reading

Study examines direct-to-consumer stem cell clinics in six Southwestern states

This direct-to-consumer stem cell marketplace has come under increasing scrutiny, but relatively little is known about the clinics that deliver these treatments or how the treatments they offer align with the expertise of the practitioners providing them. In a paper published August 1 in the journal Stem Cell Reports, investigators Continue Reading

Targeting a blood stem cell subset shows lasting, therapeutically relevant gene editing

In a paper published in the July 31 issue of Science Translational Medicine, researchers at Fred Hutchinson Cancer Research Center used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, including sickle cell disease and beta-thalassemia. It’s the first time that scientists Continue Reading

Enzyme responsible for dangerous properties of brain tumor stem cells

The relapse of brain tumors after therapy is driven by cancer stem cells that were not affected by the treatment. In mouse models of glioblastoma, scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) were now looking for molecular markers that specifically characterize brain tumor stem cells. They identified Continue Reading

Enzyme responsible for dangerous properties of brain tumor stem cells

Credit: CC0 Public Domain The relapse of brain tumors after therapy is driven by cancer stem cells that were not affected by the treatment. In mouse models of glioblastoma, scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) were now looking for molecular markers that specifically characterize brain tumor Continue Reading