Chair yoga more effective than music therapy in older adults with advanced dementia

As dementia progresses, the ability to participate in exercise programs declines. Sticking to a program also becomes challenging because of impaired cognition, mobility issues or risk of falls and fractures—some exercise regimens are just too complicated or physically demanding. Although studies have shown the benefits of physical activity on dementia, Continue Reading

Laser therapy gains credibility as effective option for treating vaginal problems

Nearly 50% of menopausal women complain of vaginal dryness, itching, and burning, among other commonly reported menopause symptoms. Laser therapy is one of the newer techniques for addressing these problems. A new study suggests that it is as effective and safe as vaginal estrogen in improving sexual and urinary functionality. Continue Reading

Elderly who start thiopurine therapy for IBD have higher risk for adverse events

(HealthDay)—Elderly patients with inflammatory bowel disease (IBD) are at higher risk for adverse events (AEs) related to the use of thiopurines, according to a study published in the October issue of Alimentary Pharmacology and Therapeutics. Margalida Calafat, Ph.D., of the Hospital Son Llàtzer in Mallorca, Spain, and colleagues identified adult Continue Reading

First targeted therapy for cholangiocarcinoma shows clinical benefit in phase III trial

New data have shown for the first time that targeted therapy can improve the outcome of patients diagnosed with advanced cholangiocarcinoma. Cholangiocarcinoma is a subtype of bile duct cancer with aggressive behaviour and poor prognosis. Despite the low incidence, most patients die from the disease and therefore new effective therapies Continue Reading

First prostate cancer therapy to target genes delays cancer progression

For the first time, prostate cancer has been treated based on the genetic makeup of the cancer, resulting in delayed disease progression, delayed time to pain progression, and potentially extending lives in patients with advanced, metastatic prostate cancer, reports a large, international phase 3 trial. One of the principal investigators Continue Reading

Targeted therapy drug helps women with aggressive breast cancer live longer

A study led by UCLA researchers found that adding ribociclib, a targeted therapy drug, to standard hormone therapy has been shown to significantly improve overall survival in postmenopausal women with advanced hormone-receptor positive/HER2- breast cancer, one of the most common forms of the disease. The results were presented during the Continue Reading

Immune therapy eliminates tumour cells in early triple negative breast cancer

Immune therapy added to chemotherapy improves pathological complete response in patients with early triple negative breast cancer, according to late breaking results from the KEYNOTE-522 trial presented at the ESMO Congress 2019 in Barcelona, Spain. Interim results from the study, which is the first phase III trial of immunotherapy in Continue Reading

 A model for brain activity during brain stimulation therapy

Brain stimulation, where targeted electrical impulses are directly applied to a patient’s brain, is already an effective therapy for depression, epilepsy, Parkinson’s and other neurological disorders, but many more applications are on the horizon. Clinicians and researchers believe the technique could be used to restore or improve memory and motor Continue Reading

First CAR T cell therapy targeting B cell-activating factor receptor eradicates blood cancers

The first CAR T cell therapy targeting the B cell-activating factor receptor on cancerous cells eradicated CD19-targeted therapy-resistant human leukemia and lymphoma cells in animal models, according to City of Hope research published today in Science Translational Medicine. The new therapy will be used in a clinical trial next year Continue Reading

World’s first gene therapy for glycogen storage disease produces remarkable results

At the Association for Glycogen Storage Disease’s 41st Annual Conference, Dr. David Weinstein of UConn School of Medicine and Connecticut Children’s presented his groundbreaking, one-year clinical trial results for the novel gene therapy treatment for glycogen storage disease (GSD). The rare and deadly genetic liver disorder, GSD type Ia, affects Continue Reading

CAR T cell therapy: On the cusp of ‘an immunotherapy revolution’?

A deeper understanding of the immune system’s role in controlling cancer has helped drive “an immunotherapy revolution,” offering hope for many patients with previously incurable cancers, including children, doctors have concluded in a new report. The assessment, from two Stanford University doctors, is part of their broader analysis on lessons Continue Reading

Initiating empirical therapy for sepsis reduces blood culture sensitivity

(HealthDay)—When empirical antimicrobial therapy is initiated in patients with severe manifestations of sepsis, the sensitivity of blood cultures drawn shortly after treatment initiation is reduced, according to a study published online Sept. 17 in the Annals of Internal Medicine. Matthew P. Cheng, M.D., from Brigham and Women’s Hospital and Harvard Continue Reading